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Herb, nutrient, and drug interactions: There was not enough data available at that time to determine the relative risk of death or of death from heart disease. Several are available as fixed-dose combinations , to reduce pill burden and simplify administration. However, following a meta-analysis in that linked the medication's use to an increased risk of heart attack , [] concerns were raised over the safety of medicines containing rosiglitazone. Liquid metformin is sold under the name Riomet in India. Clinical Pharmacology and Therapeutics. Metformin may be quantified in blood, plasma, or serum to monitor therapy, confirm a diagnosis of poisoning, or assist in a forensic death investigation.

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